http://peptide-guide.com/

Melanotan One, Scenesse, Afamelanotide (M-I) Dose:

Light:  .5mg
Common:  1mg
Large:  2mg

Melanotan/Afamelanotide is a synthetic version of melanocyte stimulating hormone (a-MSH).  Afamelanotide treatment induces skin pigmentation through melanogenisis, the production of melanin.  Melanin prevents cellular damage in the skin by absorbing, reflecting and refracting light.  Melanotan reduces sun damage to UV exposed skin in those with sun allergies.

Melanotan Results: Melanotan favors production of eumelanin (black/brown) over pheomelanin (red/yellow) pigment.  Injecting this linear amino acid structure peptide offers super-physiological levels of a-MSH.  Learning the majority of secretion of a-MSH comes from the skin as opposed to the pituitary gland was a recent breakthrough in medical science.  Those with a Fitzpatrick skin type I-III classification have natural levels of a-MSH that are hardly detectable.  The fair skinned can achieve a photoprotective tan with synthetic MSH.

Research Use: The half-life of Melanotan peptides is very brief.  Afamelanotide is being developed in implant form for the ease of use in dermatology.  The implant contains 16mg which has a controlled release effecting melanin density for months.  Melanotan One is offered in research peptide form (20mg Melanotan One).  Peptide Melanotan One gives the user greater control over dosing, however requires injections and expertise.

Lifestyle: Melanocortins have the potential to be the next big thing in lifestyle drugs (Viagra, Botox, etc).  Patients who benefit from treatment have such variations when it comes to their goals, expectations and genetics.  Melanotan can be appropriately used continuously as well as intermittently.  Dose timing and missing doses are generally not of much concern.  Missing a dose and taking time off is the name of the game for the lifestyle peptide.

Recommended Therapy: Intermittent therapy, lasting 10 days (skin type III) to 6 months (skin type I) works well.  Take note how long after your Melanotan administration melanin density stays elevated.

Molecule: Two amino acids present in the bodies natural a-MSH have been changed in production of Afamelanotide creating more stablity.  Melanotan only works when injected subcutaneously.
Amino acid sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

Approval: Melanotan is still undergoing clinical trials and has not reached approved status.  People use on the pretenses and understanding that it is for research purposes only.  Users may suffer from slight nausea and flushing after subcutaneous injection; however it is reported to be mild and pass quickly.

Safety First: Melanotan One is a selective agonist of the MC1R (Melanocortin 1 receptor) and does not have aphrodisiac effects.  Melanotan One does not cross the blood brain barrier.  It is for this reason Afamelanotide has continued clinical trials.  The fat/weight loss, appetite suppression, libido effects are found in Melanotan 2 and Bremelanotide (PT-141).

Patience: Melanotan One is less efficacious than its counterpart Melanotan 2 for achieving a dark tan.  Afamelanotide will therefore require 8-10x the dosage to see comparable results.  Melanotan One users want minimum side and peripheral effects with a focus on photoprotection.  Be patient and prepared through your Melanotan journey.

Administration of Research Melanotan
Safe and controlled administration of Afamelanotide for research is done much like that of Melanotan 2.  Melanotan One offered as a peptide in a multi-dose sterile vial is desirable.  Implants, nasal sprays and pills are not applicable/efficacious at the present time.

Melanotan Treatment
Allow time before seeing UV exposure.  Sunburn is to be avoided.

Example-  Skin type II, 180lb male
Day 1-2:  .5mg each night
Day 3-6:  1mg when convenient
Day 7-10:  2mg when convenient
Day 11 on forward:  begin dosing ~6mg/week

Day 7:  10min sun bed session.  (Cover face/genitals/sun damage, use lotion, etc)
Day 9:  10min sun bed session.
Day 11:  15min sun bed session

Dosing According to Skin Type

Fitzpatrick Skin Type I:  1mg-2mg/day.  100mg total may be necessary to achieve desired color.  UV exposure after at least 20mg in system
Fitzpatrick Skin Type II:  .75mg-1.5mg/day.  60mg should be sufficient to get color.  UV exposure after 10-20mg
Fitzpatrick Skin Type III:  .5mg-1mg/day.  A sunless tan may be realistic here
Fitzpatrick Skin Type IV and beyond:  Do not use Melanotan

Melanotan Video from Australia

Melanotan can develop a protective tan in users.  A natural tan is developed in response to cell damage caused by UV radiation.  Ultraviolet rays penetrate the upper layers of the skin, triggering a-MSH, stimulating melanin production.  Melanin deposits act as a natural sunblock at the cellular level.  Melanotan tanning injections may offer a way to bring upon a safe, cosmetic tan with less damage.

Melanotan Results

Reconstituting

Swab the stopper of both your M-I vial and the vial of the dilutent (bacteriostatic water) with an alcohol swab.

Take a syringe and draw up your bact water. The amount isn’t critical, other than making sure you know exactly how much you have used. The best rule of thumb is choose an amount that will make measuring the final product easy.

Example- 2ml(cc) per 20mg vial of M-I would mean each 10 marks on a U100 insulin syringe would equal 1mg of Melanotan (M-I)
Example- 1ml(cc) per 10mg vial of M-I would mean each 10 marks on a U100 insulin syringe would equal 1mg of Melanotan (M-I)

Avoid shooting the dilutent directly on the lyophilized powder.  The powder should almost instantly dissolve.  Gently swirl until the liquid is clear if powder did not dissolve upon contact.

Store your unused M-I in the refrigerator.  Once reconstituted, the Melanotan should be good for 4-6 weeks in the refrigerator.

Measuring

After successfully reconstituting your peptide, now measure the desired amount out for injection. You will want to use a U100 insulin syringe to draw out your M-I.

cont’d

The rise, fall, and stealth return of the world’s first medically proven aphrodisiac.

As soon as the bremelanotide (a.k.a. PT-141) arrived in the mail, I shook the white crystal onto a mirror and began to chop it into powder. I snorted some and a bitter taste began its steady descent down the back of my throat. But I wasn’t about to complain. Thanks to a website called Tanresearch.com and $60, I finally had my hands on the most revolutionary sex drug ever created. This potion had undergone studies for almost a decade in a quest to make it the first-ever FDA-approved aphrodisiac….

ab workouts

Melanocortin peptide therapeutics: Milestones, Clinical studies

Abstract

Melanocortins (MCs) are a family of multifunctional peptide hormones. Several superpotent, prolonged acting, enzymatically resistant, MC analogs have been designed and synthesized to help clarify the nature and role of MCs and their receptors (MCRs) in physiological functions. Two of these analogs, a linear peptide, Melanotan One, and a cyclic truncated peptide, Melanotan 2 have been tested clinically for studies on tanning of the skin (Melanotan One) and for diagnosis and treatment of male erectile dysfunction (Melanotan 2). A MT-2 analog, PT-141 (Bremelanotide) is undergoing clinical trials. Melanotan One may provide a therapeutic tan with the potential to lower the risk of skin cancer. PT-141 may improve sexual functionality in both males and females.

Please check out our new Melanotan Study forum at MelanotanHQ (register to view)

Buy MT-2, PT-141, Melanotan Wholesale Peptides from Opresource:

Photoprotection is the beginning

Eumelanin over Pheomelanin

Melanotan One is a selective agonist of the MC1R (melanocortin 1 receptor).  As an analogue of the naturally occurring melanocortin alpha-MSH, Melanotan One delivers a photoprotective response through the MC1 receptor.  Binding to melanocyte cells, it begins a series of actions and reactions that result in the melanocyte favoring the production of eumelanin (black/brown) over pheomelanin (red/yellow).

Melanocytes creating eumelanin, thereby increasing pigmentation of the skin and thus providing photoprotection is the therapeutic benefit intended from the administration of Melanotan One.

Melanin is the natural substance that gives color (pigment) to hair, skin, and the iris.



Tyrosinase is responsible for the first step in melanin production.  Tyronsinase is involved in melanogenesis resulting in heightened levels of the enzyme in the melanocyte.  The level of enzymes melanocytes have dictate whether the cell will create eumelanin (photoprotective black/brown pigment).



Visually see natural pheomelanin to eumelanin (via Melanotan peptides) production:

Above photo depicts natural pale skin which turns red (pheomelanin) in the sun


Synthetic a-MSH use favoring eumelanin production which turns black/brown in the sun


Photo highlights the melanin color of moderation.  Sunless tan?

Photoprotection is only the beginning!

http://melanotanhq.com/forum/

MT-2: When does the Magic Happen?

Melanotan 2 has many effects users seek out.  The only synthetic aphrodisiac on the market, the effects of Bremelantide (PT-141) via MT-2 is amazing.  Melanotan 2 can indeed be that magic Barbie peptide which goes beyond Bremelanotide affecting ones facial hair, photoprotection, and weight loss!  A dark sexy beard is often a unique perk for those with light or patchy facial hair.  Appetite reduction, energy and increasing gym productivity are more positives of MT-2.  Then of course, the magic happens when the tan sets in and is dialed in.  Photo-protection through MT-2 is certainly the most impressive characteristic which results in life changing opportunity.


Melanotan 2 and Libido

MT-2 can consciously be used as an advantage in the libido dept.  Good times are right around the corner when used properly.  Be aware that dosing too high too soon leads to a bad time.  Dose escalation and assessing ones tolerance is crucial.

For most users, getting sick and experiencing nausea is not high on the agenda.  To avoid the initial post injection nausea MT-2 users carefully assess tolerance.  Starting extremely low and escalating the dose is wise.  A .25mg dose is very small and for first time users it is advised to dose on a full stomach, an anti-histamine in your system, at around bedtime.  This way a user has the odds on their side that they will experience nothing from the injection  The injection site sometimes itches for a few minutes or can have some discomfort.  A seasoned user will not likely encounter any side effects.

The ultimate synthetic aphrodisiac experience can be seen with proper planned MT-2 use.  When your body can handle and is ready for that 1-2mg dose, 2-4 hours before the encounter…game on!  There are many variables that come into play in regards to PT-141/MT-2/the synthetic aphrodisiac.  Variables such as sex (male/female – works for both), timing, dose, stress/mood and expectations all are factors.

Depending on your objectives, MT-2 can increase one’s libido in a matter of hours or a week or two before realizing the effects.  Many times users really dont pay attention or are aware of the libido properties.  Often men will share that their morning wood is something to take note of.  Women claim the effects are long lasting, up to 3 days after administration.  Others will be kept up at night with desire  Then some can be in sync with their MT-2 libido tolerance and plan a aphrodisiac date night to be remembered

Check out our between the sheets forum specific to the aphrodisiac:
http://melanotanhq.com/forum/index.php?board=17.0

MT-2 Black Beard
For the blond, strawberry, ginger, auburn, etc hair types out there the MT-2 will effect facial hair growing in.  Very rare that hair color will change on your head.  With extensive use it can effect body hair…but again, rare.  Beginning MT-2 users who are loading up, assessing their tolerances and building up their photoprotective skin via MT-2 will start to see the beard coming in darker approximately 2-3 weeks into usage.  Somewhere between 20-30mg a user should be able to see a darker color.

Many enjoy this effect and grow out or sport their shadow with more frequency.  One issue which users should be aware of is that they should still be paying close attention to hygiene & upkeep.  With the adding emphasis on tanning and/or exercise…one shouldn’t necessarily let the facial hair get out of control – even with it looking attractive.  Every now and again users will report an increase in oil.  You want a black beard, not black heads.  Also you want to keep the pores straight and not invite unnecessary ingrown hairs  Flattering compliments about facial hair is not the norm for many Melanotan users, until they experience it!

Rough photo that gives an idea of the darkened facial hair difference:
http://melanotanhq.com/forum/index.php?topic=154.msg406#msg406


The Barbie Effect
Melanotan 2 has been coined the barbie drug by the media etc years back as it was found to make one tan, skinny and feel on top of the world (aphrodisiac).  It will indeed decrease your appetite.  Some users use it for this reason as there are more and more studies on melacortins and obesity.  Folks who are not interested in appetite reduction have to work on dosing at appropriate times, be aware of not over consuming when the MT-2 isnt present in the system and dose at the right mg  Some advocate smoking herb before injects to not only hedge any nausea, but to keep the appetite functioning at a high capacity.  Other peptides like HGH and some of the growth hormone anti-aging secretalogues also work to increase appetite and give an edge to their skin/rejuvenation.  Over eating can be factored in according to the desired lifestyle – have yet to see any user logs where anyone gets fat and tan on MT-2.

The combination of the aphrodisiac, the sun light, weight loss, complements…they are all part of the barbie phenomenon.  Users frequently comment about increased productivity in the gym – nothing scientific to back these claims.  Some studies in regards to melancortins and insulin sensivity, etc are out there.  Stay tuned until these are discussed further.

On the flip side users can also find themselves lethargic on MT-2.  If Mt-2 is making you tired, take a few days off from dosing as it will not hurt a thing.  It is all about finding the right Barbie balance

Melanotan in the news:  http://melanotanhq.com/forum/index.php?board=7.0

The Magic Tan
As a seasoned Melanotan peptide user, I recall the 5th or 6th week of use being ah ha moment.  There were several epiphanies had during the course of experimentation and experience.  The feeling of having the superior tan (as compared to a spray tan) which was my own was tops.  Beyond that, the experience of being on a lake for extended hours…becoming more tan, not burning…what a thrill.  Freedom to be in the sun and from the sun is a topic I hope to elaborate on in depth.

Most users experience doubt, concern, remorse…all part of the initial roller-coaster.  I know I was crunching numbers, questioning sanity in regards to UV ray exposure, the injections…the buying process…it all sucks.  That 10 day to two week mark where some one calls out your awkward pigmentation is not good for the esteem.  At a month where your tan surpasses the pigmentation…ahhh, good times!  You start to dial in your tan which can resemble that of a quality spray tan.  But now you can continue to live outside, do cardio in the gym and swim without fear of your spray on mess transferring off you and often onto your clothes, bed sheets, and other half.  MT-2 users are able to forget all that and leave it in the past!

Melanotan magic happens through diligence, understanding and appreciation for the skin.  Love and take care of yourself!  Melanotan peptides enhance many lifestyles.  They should not become more trouble than they are worth.  Check out as much info as possible before diving in head first.  Find out each reason you should not use before a decision is made.  Prepare for everything and expect results – these are some of the most efficacious research peptides on the market.

Melanotan user logs:  http://melanotanhq.com/forum/index.php?board=8.0
Before and after photos:  http://melanotanhq.com/forum/index.php?board=15.0

Things you should know:

Dose escalation. With Melanotan 2, a good starting point is .25 mg. The goal is to find the smallest effective dose possible while limiting side-effects. Everyone is different, not all suppliers are created equal.

Anti-histamines. Anti-histamine use can help reduce post injection nausea from MT-2. The anti-histamine reduces the probability of the body reacting that way to the introduction of the foreign compound. Claritin (Loratadine), Zyrtec (Cetirizine), Benadryl (Diphenhydramine) are appropriate.

Cover your eyes and face. Fair skinned MT-2 users particularly. As limited UV exposure is essential for a natural looking tan, experiment with your body first. Try and avoid exposing your face until your 2nd or 3rd Melanotan cycle. Many out there overexpose themselves leaving their faces looking extra dark. Purple lips, wrinkles and freckles are just some of the lovely characteristics misuse can bring. Your face is sensitive, protect it. Achieving a balanced tan is what most of us are after.

Ignore dosing charts. Rely on a common sense approach of dose escalation and experimentation. Charts which float around the net often have not kept up with the collective and advocate dangerously high dosages.

Read current guides. Find the best information from many sources. Misinformation, trends, fades, and propaganda run rampant in the marketplace. Successful how to guides often share many similar principles which are extremely helpful to pay attention to.

Rely on referrals. A seller who has stood the test of time and has referrals is likely looking out for you. A seller or area touting concerns about fillers, standards or origins often are misguided.

Log & support user logs. Creating or simply participating in user logs offers insight into the thought process of the MT-2 user. The market relies on the collective knowledge. Rare there are detailed instructions applicable to you and your specific objectives. Ask questions. You will be surprised how many tricks of the trade rise to the surface.

Weight-loss. Clinical data is on the rise. For now, many users believe MT-2 has fat loss/appetite suppression possibilities. Maximize fat loss when you use MT-2 on days or during time periods when you are fasting or in a caloric deficit.

Travel sized Peptides. Although reconstituted MT-2 lasts for months when refrigerated, peptides are perishable items and require a certain level of care. 10mg MT-2 has been the industry standard size. With the dosage charts on the decrease, dose escalation on the increase, 5mg MT-2 offers further efficacy. Rather take a 10mg or 5mg MT-2 on a 4 day vacation? What about a 2mg PT-141 for the weekend? These are some options to take note of. From experience I can tell you there is not much exciting about bringing a 10mg vial on a trip only to pitch 5-8mg of the product in the trash before the flight home.

Melanotan II Instruction

Bremelanotide (PT-141/MT-II) Aphrodisiac Experiences

2003 Before and After Photo



Bremelanotide (PT-141) Guide

First time MT-2 experience

PT-141 On Vacation

Melanotan Promises to Make You Tan, AND Thin!
By Michele Hickford

A VERY happy accident

In the mid-’80s a research team at the sun-drenched University of Arizona was working on skin cancer prevention. Instead of slathering sun blocks on the outside, the researchers were searching for protection from the inside out, to enhance the body’s own ability to generate a safe, slow tan. Team Arizona, which included endocrinologist Mac Hadley, dermatologist Norman Levine, and pharmacology research Robert Dorr discovered a synthetic hormone a thousand times stronger than the body’s own tanning triggers. They called it Melanotan I and later Melanotan II (MT-II) and began testing it on a group of men.

The research team hoped to create a safe, protective tan for users without damaging sunlight. But the golden tan wasn’t the only reason the research subjects were glowing.

According to Dr. Dorr, “Even at the very low starting dose of Melanotan II, every subject had an erection.” You mean like, constantly?

Rather than simple vascular stimulation, like Viagra, Melanotan apparently directly stimulates the hypothalamus in the brain. So instead of tackling the mechanics of impotence, Melanotan could potentially jump-start desire. And not just in men. On Melanotan, female lab rodents tripled their levels of courtship behavior. (Not sure what that would be for rodents, but I assume it has nothing to do with pedicures, hair-tossing or flirtatious text messages.)

But it gets even better.

“After about 10 days of taking Melanotan II, I lost about 10 pounds,” said Hadley, who joined the clinical trial after the testers began reporting promising results.

The Melanotan molecule also targets an appetite-suppression receptor in the body which “causes short term feelings of fullness or nausea,” according to Dorr, “You could theoretically get tanned and have a lot of erectile activity and you might actually start to lose weight.” Wowser! I don’t know which one I want first!
Cont’d

Sunless.com

Years ago, the feature Sunless Tanning: Facts and Myths attacked the effectiveness of tanning pills.

But tanning pills have proven to be the hardest sunless tanning myth to kill. Nutritional supplements, or tanning pills, that “promote” tanning proliferate, and ads for them are everywhere.

There are only two things that matter in the production of melanin: your genetics and your degree of exposure to ultraviolet radiation. Nutrition simply does not play a part for the normal, well nourished individual.

To make this clear, I’ll go over the facts of tanning [melanocytes - melanogenesis], describe three medical conditions that negatively effect tanning, summarize drugs that can affect melanogenesis, and, finally, analyze three typical tanning pills.

Cont’d

TV3 reports on Melanotan II and how the tanning peptide injection effects

melanin as well as aphrodisiac/libido enhancement & appetite suppression: